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Free Radical Research
Group - Tony Kettle
Recent Selected
Publications
2008
- Meotti, F.C., Senthilmohan, R., Harwood, D.T., Missau, F.C.,
Pizzolatti, M.G., and Kettle, A.J. Myricitrin as a substrate
and inhibitor of myeloperoxidase: Implications for the pharmacological
effects of flavonoids. Free Radic Biol Med 44: 109–120 (2008). PubMed
link
2007
- Akerström, B., Maghzal, G.J., Winterbourn, C.C., and Kettle,
A.J. The lipocalin alpha1-microglobulin has radical scavenging
activity. J Biol Chem 282: 31493–31503 (2007). PubMed
link
- Kettle, A.J., Anderson, R.F., Hampton, M.B., and Winterbourn,
C.C. Reactions of superoxide with myeloperoxidase. Biochemistry
46: 4888–4897 (2007). PubMed
link
2006
- Brooks, W.M., Lash, H., Kettle, A.J., and Epton, M.J. Optimising
hydrogen peroxide measurement in exhaled breath condensate. Redox
Rep 11: 78–84 (2006). PubMed
link
- Senthilmohan, R., and Kettle, A.J. Bromination and
chlorination reactions of myeloperoxidase at physiological concentrations
of bromide and chloride. Arch Biochem Biophys 445: 235–244
(2006). PubMed
link
- Harwood, D.T., Kettle, A.J., and Winterbourn, C.C. Production
of glutathione sulfonamide and dehydroglutathione from GSH by myeloperoxidase-derived
oxidants and detection using a novel LC-MS/MS method. Biochem J 399:
161–168 (2006). PubMed
link
- Winterbourn, C.C., Hampton, M.B., Livesey, J.H., and Kettle,
A.J. Modeling the reactions of superoxide and myeloperoxidase
in the neutrophil phagosome: implications for microbial killing.
J Biol Chem 281: 39860–39869 (2006). PubMed
link
- van Dalen, C.J., Winterbourn, C.C., and Kettle, A.J. Mechanism
of nitrite oxidation by eosinophil peroxidase: implications for oxidant
production and nitration by eosinophils. Biochem J 394: 707–713
(2006). PubMed
link
2005
- Dypbukt, J.M., Bishop, C., Brooks, W.M., Thong, B., Eriksson,
H., and Kettle, A.J. A sensitive and selective assay for
chloramine production by myeloperoxidase. Free Radic Biol Med 39:
1468–1477
(2005). PubMed
link
- Kettle, A.J., and Winterbourn, C.C. Do neutrophils
produce ozone? An appraisal of current evidence. Biofactors 24: 41–45
(2005). PubMed
link
- Ximenes, V.F., Silva Sde, O., Rodrigues, M.R., Catalani, L.H.,
Maghzal, G.J., Kettle, A.J., and Campa, A. Superoxide-dependent
oxidation of melatonin by myeloperoxidase. J Biol Chem 280: 38160–38169
(2005). PubMed
link
2004
- Kettle, A.J., Chan, T., Osberg, I., Senthilmohan, R., Chapman,
A.L., Mocatta, T.J., and Wagener, J.S. Myeloperoxidase
and protein oxidation in the airways of young children with cystic
fibrosis.
Am J Respir Crit Care Med 170: 1317–1323 (2004). PubMed
link
- Kettle, A.J., Clark, B.M., and Winterbourn, C.C. Superoxide
converts indigo carmine to isatin sulfonic acid: Implications for
the hypothesis that neutrophils produce ozone. J Biol Chem 279: 18521–18525
(2004). PubMed
link
- Winterbourn, C.C., and Kettle, A.J. Reactions of
superoxide with myeloperoxidase and its products. Jpn J Infect Dis
57:S31–33
(2004). PubMed
link
2003
- Buss, I.H., Senthilmohan, R., Darlow, B.A., Mogridge, N., Kettle,
A.J., and Winterbourn, C.C. 3-Chlorotyrosine as a marker
of protein damage by myeloperoxidase in tracheal aspirates from
preterm
infants: association with adverse respiratory outcome. Pediatr
Res 53: 455–462 (2003). PubMed
link
- Chapman, A.L.P., Winterbourn, C.C., Brennan, S.O., Jordan,
T.W., and Kettle, A.J. Characterization of non-covalent
oligomers of proteins treated with hypochlorous acid. Biochem J
375: 33–40
(2003). PubMed
link
- Winterbourn, C.C. and Kettle, A.J. Radical–radical
reactions of superoxide: a potential route to toxicity. Biochem Biophys
Res Comm 305: 729–36 (2003). PubMed
link
2002
- Aldridge, R.E., Chan, T., van Dalen, C.J., Senthilmohan, R.,
Winn, M., Venge, P., Town, I., and Kettle, A. J. Eosinophil
peroxidase produces hypobromous acid in the airways of stable asthmatics.
Free Radic Biol Med 33: 847–856 (2002). PubMed
link
- Chapman, A.L.P., Hampton, M.B., Senthilmohan, R., Winterbourn,
C.C., and Kettle, A.J. Chlorination of bacterial and neutrophil
proteins during phagocytosis and killing of Staphylococcus aureus.
J Biol Chem 277:9757–62 (2002). PubMed
link
- Upston, J.M., Niu, X., Brown, A.J., Mashima, R., Wang, H.,
Senthilmohan, R., Kettle, A.J., Dean, R.T., and Stocker, R. Disease
stage-dependent accumulation of lipid and protein oxidation products
in human atherosclerosis. Am J Pathol 160:701–10 (2002). PubMed
link
2001
- Kettle, A. J. and Winterbourn, C. C. A kinetic
analysis of the catalase activity of myeloperoxidase. Biochemistry 40:10204-10212
(2001).
- Van Dalen, C. J. and Kettle, A. J. Substrates and products
of eosinophil peroxidase. Biochem. J 358:233-239 (2001).
2000
- Van Dalen, C. J., Winterbourn, C. C., Senthilmohan , R., and Kettle,
A. J. Nitrite as a substrate and inhibitor of myeloperoxidase:
Implications for nitration and hypochlorous acid production at sites
of inflammation. J. Biol. Chem. 275:11638-11644 (2000).
- Vile, G. F., Rothwell, L. A., and Kettle, A. J. Initiation
of rapid, p53-dependent growth arrest in cultured human skin fibroblasts
by reactive chlorine species. Arch. Biochem. Biophys. 377:122-128
(2000).
- Chapman, A. L. P., Senthilmohan , R., Winterbourn, C. C., and Kettle,
A. J. Comparison of mono and dichlorinated tyrosines with carbonyls
for detection of hypochlorous acid-modified proteins. Arch. Biochem.
Biophys. 377:95-100 (2000).
- Winterbourn, C. C., Vissers, M. C. M., and Kettle, A. J. Myeloperoxidase.
Curr. Opin. Hematol. 7:53-58 (2000).
- Winterbourn, C. C. and Kettle, A. J. Biomarkers of myeloperoxidase-derived
hypochlorous acid. Free Radical Biol. Med. 29:403-409 (2000).
- Burner, U., Furtmuller, P. G., Kettle, A. J., Koppenol, W. H., and
Obinger, C. Mechanism of reaction of myeloperoxidase
with nitrite. J. Biol. Chem. 275:20597-20601 (2000).
- Kettle, A. J. and Candaeis, L. P. Oxidation
of tryptophan by redox intermediates of myeloperoxidase and inhibition
of hypochlorous acid production. Redox Report 5:179-184 (2000),.
1999
- Burner, U., Obinger, C., Paumann, M., Fürtmuller, P. G., and
Kettle, A. J. Transient and steady-state kinetics of the oxidation
of substituted benzoic acid hydrazides by myeloperoxidase. J. Biol.
Chem. 274:9494-9592 (1999).
- Kettle, A. J. Detection of 3-chlorotyrosine in proteins exposed
to neutrophil oxidants. Methods Enzymol. 300 Part B:111-120 (1999).
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