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Recent research publications - (request
reprints)
- Glubb, D.M., McHugh, P.C., Deng, S., Joyce,P.R.,
Kennedy, M.A. (2009) Association of a functional polymorphism
in the adrenomedullin gene (ADM) with response to paroxetine.
Pharmacogenomics Journal (Accepted)
- Harley JA, Roberts
RL, Joyce PR, Mulder RT, Luty SE, Frampton CM, Kennedy
MA. (2009) Orosomucoid influences
the response to antidepressants in major depressive disorder.
J. Psychopharmacol. Apr 24. [Epub ahead of print]
- McHugh, P.M., Rogers, G.R., Glubb, D.M., Allington,
M., Joyce, P.R., Kennedy, M.A. (2009) Proteomic analysis
of rat hippocampus exposed to the antidepressant paroxetine.
J Psychopharmacol. 2009 Apr 3. [Epub ahead of print]
- Doudney, K., JA Harley, JF Pearson, A Miller, A Aitchison,
MA Kennedy, RJ Porter, JL Elmslie and PR Joyce. (2009)
Upstream genetic variant near INSIG2, influences response
to carnitine supplementation in bipolar patients with
valproate induced weight gain. Acta Neuropsychiatrica.
3, 133–140
- Glubb, D.M., Joyce, P.R., Kennedy, M.A. (2009) Expression
and association analyses of promoter variants of the
neurogenic gene HES6, a candidate gene for mood disorder
susceptibility and antidepressant response. Neurosci.
Let. 460, 1985-190.
- McHugh, P.C., Joyce, P.R., Kennedy,
M.A. (2009) Polymorphisms of sepiapterin reductase gene
alter promoter
activity
and may influence risk of bipolar disorder. Pharmacogenetics
and Genomics 19, 330-337
- Stamp,L.K., O’Donnell,
J.L., Chapman, P.T., Barclay, M.L., Kennedy, M.A., Frampton,
C.M.A., Roberts,
R.L. (2008) Lack of association between HLA-G 14bp
in-del polymorphism and response to long-term therapy
with methotrexate
response in rheumatoid arthritis. Annals of the Rheumatic
Diseases 68, 154-5
- McHugh, P.M., Rogers,G.M.,
Glubb, D.M., Allington, M.D., Hughes, M., Joyce,
P.R., and Kennedy, M.A. (2008) Downregulation
of Cyclin D1 (Ccnd1) and Hairy Enhancer of Split
6 (Hes6) in rat hippocampus after chronic exposure
to the antidepressant
paroxetine. Acta Neuropsychiatrica 20, 307-313
- Clark, DWJ, Ashton, JA, Wallace, AK, Zhou, L,
Kennedy, MA. (2008) Pharmacogenetic investigation
using a pharmacovigilance
database. PharmacoVigilance Review 2, 9-13.
- Roberts, R.L., Gearry, R.B., Kennedy, M.A.,
Barclay, M.L. (2008) Beyond TPMT: genetic
influences on thiopurine
drug responses in inflammatory bowel disease.
Personalized Medicine 5, 233-248.
- Lea RA, Roberts RL, Green MR, Chambers
GK, Kennedy MA. (2008) Allele Frequency
Differences of Cytochrome
P450 Polymorphisms in New Zealand Maori.
NZ Med
J 121, 33-37
- Porter, R.L., Mulder, R.T., Joyce,
P.R., Miller, A.L., Kennedy, M.A.
(2008) Tryptophan
hydroxylase
gene (TPH1)
and peripheral tryptophan levels
in depression. J Affect Disorders
109, 209-212
- Roberts,R.L, Gearry,R., Sies,C.,
George,P., Burt,M., Marinaki,A.,
Barclay,M., Kennedy,
M.A. (2008). Trinucleotide
repeat variants in the promoter
of the thiopurine S-methyltransferase
gene of
patients exhibiting
ultra-high enzyme activity.
Pharmacogenetics and Genomics
18, 434-438.
- McHugh, P.M., Rogers, G.R., Loudon, B., Glubb,
D.G., Joyce, P.R., Kennedy, M.A. (2008) Proteomic
analysis
of embryonic stem cell-derived neural cells exposed
to the antidepressant paroxetine. Journal of Neuroscience
Research 86, 306-316
- Roberts RL, Hollis-Moffatt JE, Gearry RB, Kennedy
MA, Barclay ML, Merriman TR. (2008) Confirmation of association
of NCF4 and IRGM with ileal Crohn’s disease in a
population-based cohort. Genes & Immunity 9, 561-5
- Littlejohn,
M.D., Palmer, B.R. Pilbrow. A., Richards, A.M., Frampton,
C.M., Troughton, R.W.,
Cameron, A.V,
Kennedy, M.A. (2008) Ile164 variant of beta
2-adrenoceptor does not influence outcome in congestive
heart failure but may interact with beta-blocker
treatment.
European
Journal of Heart Failure 10, 55-59
- Roberts RL, Gearry RB, Hollis-Moffatt JE,
Miller AL, Reid J, Abkevich V, Timms KM, Gutin
A, Lanchbury
JS,
Merriman TR, Barclay ML, Kennedy MA. (2007).
IL23R R381Q and ATG16L1 T300A are strongly
associated with Crohn’s
disease in a study of New Zealand Caucasians
with inflammatory bowel disease. American Journal
of Gastroenterology.
102, 1-8
- Johnstone, A., Brennan, K., Schenk, S.,
Kennedy, M., Lea, R., Fitzmaurice, P. (2007).
Benzylpiperazine
(BZP)
a recreational drug of abuse? Current knowledge
and future direction. J. Psychopharmacology
21, 888-94
- Gearry, RB, Roberts, RL, Burt, MJ,
Frampton, CMA, Chapman, BA, Collett,
JA, Shirley, P,
Allington, MDE,
Kennedy, MA, Barclay, ML. (2007) Effect
of inflammatory bowel disease classification
changes
on NOD2
genotype-phenotype associations in
a population-based cohort. Inflammatory
Bowel Diseases 13 (10): 1220-1227
- Roberts, R.L., Gearry, R.B., Barclay, M.L., Kennedy,
M.A. (2007) IMPDH1 promoter mutations in a patient exhibiting
azathioprine resistance. Pharmacogenomics J. 7, 312-317
- Kennedy, M.A. (2007)
Pharmacogenomics: single genes, whole genomes
and global networks. Personalized Medicine
4, 87-94
- Stamp, L., Roberts, R., Kennedy, M., Barclay, M., O’Donnell,
J., Chapman, P. (2006) The use of low dose methotrexate in
rheumatoid arthritis – are we entering a new
era of therapeutic drug monitoring and pharmacogenomics?
Biomedicine and Pharmacotherapy 60(10):678-87
- Priest, V.L., et al., Pharmacoeconomic analyses of azathioprine,
methotrexate and prospective pharmacogenetic
testing for the management of inflammatory bowel disease.
Pharmacoeconomics,
2006. 24(8): p. 767-781.
- Gardiner, S.J. and E.J. Begg, Pharmacogenetic
testing for drug metabolizing enzymes: is it
happening in practice?
Pharmacogenet Genomics, 2005. 15(5): p. 365-9
- Gardiner, S.J. and E.J. Begg, Pharmacogenetics, drug-metabolizing
enzymes, and clinical practice. Pharmacological
Reviews, 2006. 58(3): p. 521-590
- Gardiner, S.J., et al., Two cases of thiopurine methyltransferase
(TPMT) deficiency - a lucky save and a
near miss with azathioprine. British Journal of Clinical
Pharmacology,
2006. 62(4):
p. 473-476
- Gardiner, S.J., et al., Exposure to thiopurine drugs
through breast milk is low based on metabolite
concentrations in mother-infant pairs. British Journal
of Clinical Pharmacology,
2006. 62(4): p. 453-456
- Roberts, R.L., Kennedy, M.A. (2006) Rapid detection
of common Cytochrome P450 2D6 alleles in Caucasians.
Clinica Chemica Acta 366, 348 - 351
- Begg EJ. (2005). Individualized drug and dose: the clinical
pharmacologist's calling or curse? Clin
Exp Pharmacol Physiol 32:975-8
- Taylor, D.R., Epton, M., Kennedy, M.A., Smith, A.D.,
Isles, S., Miller, A.L., Littlejohn, M..D.,
Cowan, J.O., Hewitt, T., Swanney, M.P., Brassett, K.P.,
Herbison,
G.P.
(2005) Bronchodilator response in relation
to beta-adrenoceptor haplotype in patients with asthma.
Amer. J. Resp.
Crit. Care Med. 172, 700-703
- Gearry RB, Barclay ML. (2005). Azathioprine and 6-mercaptopurine
pharmacogenetics and metabolite monitoring
in inflammatory bowel disease. J Gastroenterol Hepatol
20:1149-57
- Kennedy MA, Roberts RL, Joyce PR (2005) Re: No evidence
of increased adverse drug reactions in
cytochrome P450 CYP2D6 poor metabolizers treated with fluoxetine
or
nortriptyline
- Authors' response. Hum Psychopharmacol
Clin Exp 20 (1): 63-64
- Gardiner, S. J., and Begg, E. J. (2005). Pharmacogenetic
testing for drug metabolizing enzymes:
is it happening in practice? Pharmacogenetics and Genomics
15, 365-369
- Joyce, P. R., Porter, R. J., Mulder, R. T., Luty, S.
E., McKenzie, J. M., Miller, A. L., and Kennedy, M.
A. (2005). Reversed diurnal variation in depression:
associations with a differential antidepressant response,
tryptophan:
large neutral amino acid ratio and serotonin
transporter polymorphisms. Psychol Med 35, 511-517
- Gearry, R. B., and Barclay, M. L. (2005). Azathioprine
and 6-mercaptopurine pharmacogenetics and
metabolite monitoring in inflammatory bowel disease. Journal
of Gastroenterology
and Hepatology 20, 1149-1157
- Roberts, R.L., et al., No evidence of increased adverse
drug reactions in cytochrome P450CYP2D6
poor metabolizers treated with fluoxetine or nortriptyline.
Human
Psychopharmacology-Clinical and Experimental, 2004.
19(1): p. 17-23
- Roberts, R.L., et al., A multiplexed allele-specific
polymerase chain reaction assay for the
detection of common thiopurine S-methyltransferase ( TPMT
) mutations.
Clinica
Chimica Acta, 2004. 341(1-2): p. 49-53
- Kennedy, M.A., G.R. Rogers, and P.R. Joyce, Pharmacogenetics
of antidepressants and mood stabilisers,
in Mood Disorders, P.R. Joyce and P. Mitchell, Editors.
2004, UNSW
Press:
Sydney. p. 223-237
- Gearry, R.B., et al., Lack of association between the
ITPA 94C > A polymorphism
and adverse effects from azathioprine.
Pharmacogenetics,
2004.
14(11): p. 779-781
- Clark, D.W.J., et al., Linking pharmacovigilance with
pharmacogenetics. Drug Safety, 2004. 27(15):
p. 1171-1184
- Joyce, P.R., et al., Age-dependent antidepressant pharmacogenomics:
polymorphisms of the serotonin transporter
and G protein beta3 subunit as predictors of response to
fluoxetine
and
nortriptyline. Int J Neuropsychopharmacol,
2003. 6(4): p. 339-46
- Gearry, R.B., et al., Thiopurine S-methyltransferase
( TPMT ) genotype does not predict adverse
drug reactions to thiopurine drugs in patients
with inflammatory bowel disease. Alimentary pharmacology & therapeutics,
2003. 18(4): p. 395-400
- Barclay, M.L., et al., Correlation of CYP2D6 genotype
with perhexiline phenotypic metabolizer
status. Pharmacogenetics, 2003. 13(10): p. 627-632
- Taylor, D.R. and M.A. Kennedy, Beta adrenergic receptor
polymorphisms and drug responses in asthmatics.
Pharmacogenomics, 2002. 3(2): p. 173-184
- Stedman, C.A.M., et al., Cytochrome P450 2D6 genotype
does not predict SSRI (fluoxetine or paroxetine)
induced hyponatraemia. Human Psychopharmacology,
2002. 17(4): p.
187-190
- Roberts, R.L., et al., A common P-glycoprotein polymorphism
is associated with nortriptyline-induced
postural hypotension in patients treated for major depression.
The
Pharmacogenomics
Journal, 2002. 2: p. 191-196
- Roberts, R.L., et al., How the pharmacogenetics of cytochrome
P450 enzymes may affect prescribing. NZ
Med. J, 2002. 115: p. 137-140
- Littlejohn, M.D., et al., Determination of beta2-adrenergic
receptor (ADRB2) haplotypes by a multiplexed
polymerase chain reaction assay. Hum Mutat, 2002. 20(6):
p. 479
- Taylor, D. and M. Kennedy, Genetic variation of the beta
2 adrenoceptor: its functional and clinical
importance in bronchial asthma. Amer. J. Pharmacogenomics,
2001. 1(3): p. 165-174
- Martin, J.H., et al., Is cytochrome P4502C9 genotype
associated with NSAID gastric ulceration? British Journal
of Clinical Pharmacology, 2001. 51(6): p. 627-630
- Roberts, R., P. Joyce, and M.A. Kennedy, Rapid and comprehensive
determination of cytochrome P450 CYP2D6
poor metabolizer genotypes by multiplex polymerase chain
reaction.
Human Mutation, 2000. 16(1): p. 77-85
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