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CCERG - Physiology Group

Selected Publications

1. Charles, C.J., Rademaker, M.T., Richards, A.M., Cooper, G.J.S., Coy, D.H., Jing, N.Y., and Nicholls, M.G. Hemodynamic, hormonal and renal effects of adrenomedullin in conscious sheep. American Journal of Physiology 41:R2040-R2047 (1997)
2. Rademaker, M.T., Charles, C.J., Lewis, L.K., Yandle, T.G., Cooper, G.J.S., Coy, D.H., Richards, A.M., and Nicholls, M.G. Beneficial hemodynamic and renal effects of adrenomedullin in an ovine model of heart failure. Circulation 96:1983-1990 (1997)
3. Rademaker, M.T., Charles, C.J., Espiner, E.A., Frampton, C.M., Nicholls, M.G., and Richards, A.M. Comparative bioactivity of atrial and brain natriuretic peptide in an ovine model of heart failure. Clinical Science 92:159-165 (1997)
4. Rademaker, M.T., Charles, C.J., Kosoglou, T., Protter, A., Espiner, E.A., Nicholls, M.G., and Richards, A.M. Clearance receptors and endopeptidase: equal role in natriuretic peptide metabolism in an ovine model of heart failure. American Journal of Physiology 273:H2372-H2379 (1997)
5. Pemberton CJ, Yandle TG, Charles CJ, Rademaker MT, Aitken GD, Espiner EA. Ovine brain natriuretic peptide in cardiac tissues and plasma: effects of cardiac hypertrophy and heart failure on tissue concentration and molecular forms. Journal of Endocrinology 155: 541-550, 1997.
6. Charles, C.J., Rademaker, M.T., Richards, A.M., Cooper, G.J.S., Coy, D.H., and Nicholls, M.G. Hemodynamic, hormonal and renal effects of intracerebroventricular adrenomedullin in conscious sheep. Endocrinology 139:1746-1751 (1998)
7. Rademaker, M.T., Charles, C.J., Espiner, E.A., Nicholls, M.G., Richards, A.M., and Kosoglou, T. Combined neutral endopeptidase and angiotensin converting enzyme inhibition in heart failure: role of natriuretic peptides and angiotensin II. Journal Cardiovascular Pharmacology 31:116-125 (1998)
8. Pemberton CJ, Yandle TG, Rademaker MT, Charles CJ, Aitken GD, Espiner EA. Amino-terminal fragment of proBNP in ovine plasma: evidence for enhanced secretion in response to cardiac overload. American Journal of Physiology 275 (44): H1200-H1208, 1998.
9. Charles CJ, Espiner EA, Nicholls MG, Rademaker MT, Richards AM. Chronic infusions of brain natriuretic peptide in conscious sheep: bioactivity at low physiological levels. Clinical Science. 95: 701-708, 1998.
10. Charles, C.J., Espiner, E.A., Nicholls, M.G., Rademaker, M.T., and Richards, A.M. Bioactivity of natriuretic peptide co-infusions; no evidence for unique effects of BNP in conscious sheep. Journal of Cardiovascular Pharmacology 33:229-236 (1999)
11. Charles CJ, Lainchbury JG, Lewis LK, Rademaker MT, Nicholls MG, Richards AM. The role of adrenomedullin. American Journal of Hypertension 12: 166-173, 1999.
12. Charles, C.J., Elliott, J.M., Nicholls, M.G., Rademaker, M.T., and Richards, A.M. Myocardial infarction with and without reperfusion in sheep: early cardiac and neurohumoral changes. Clinical Science 98:703-711 (2000)
13. Charles, C.J., Rademaker, M.T., Richards, A.M, Cooper, G.J.S., Coy D.H., and Nicholls, M.G. Adrenomedullin attenuates pressor response to administered angiotensin II in sheep on low salt diet. Journal of Cardiovascular Pharmacology 36:526-532 (2000)
14. Rademaker, M.T., Cameron, V.A., Charles, C.J., Espiner, E.A., Nicholls, M.G., Pemberton, C.J., and Richards, A.M. Neurohormones in an ovine model of compensated post-infarction left ventricular dysfunction. American Journal of Physiology 278:H731-H740 (2000)
15. Troughton RW, Rademaker MT, Powell JD, Yandle TG, Espiner EA, Frampton CM, Nicholls MG, Richards AM. Beneficial renal and hemodynamic effects of Omapatrilat in mild and severe heart failure. Hypertension 36(4): 523-530, 2000.
16. Cameron VA, Rademaker MT, Ellmers LJ, Espiner EA, Nicholls MG, Richards AM. Atrial (ANP) and brain natriuretic peptide (BNP) expression after myocardial infarction in sheep: ANP is synthesized by fibroblasts infiltrating the infarct. Endocrinology 141(12): 4690-4697, 2000.
17. Charles CJ, Elliott JM, Nicholls MG, Rademaker MT, Richards AM. Myocardial infarction with and without reperfusion in sheep: cardiac, neurohumoral and hemodynamic effects. Clinical Science 98(6): 703-711, 2000.
18. Rademaker MT and Espiner EA. Hormones of the Cardiovascular System. In: Endocrinology (4th edn). Leslie J. DeGroot & J. Larry Jameson eds. W.B. Saunders Company, Philadelphia. Vol 3, Chpt 130, pp.1791-1809, 2000.
19. Richards AM, Lainchbury JG, Nicholls MG, Rademaker MT. Adrenomedullin in heart failure: biochemical curiosity or pathophysiological player? In: Heart Failure in Clinical Practice (2nd Edition). John JV McMuurray and John GF Cleland eds. Martin Dunitz Publishers, London. pp. 105-125, 2000.
20. Charles CJ, Rademaker MT, Richards AM, Cooper GJS, Coy DH, Nicholls MG. Adrenomedullin attenuates pressor response to administered angiotensin II in sheep on low salt diet. Journal of Cardiovascular Pharmacology 36(4): 526-532, 2000.
21. Aitken GA, Cameron VA, Rademaker MT, Charles CJ, Espiner EA, Nicholls MG, Richards AM. Predominant atrial expression of ANP and BNP in paced model of heart failure. Journal of Biochemical and Molecular Biological Biophysics 5:199-207, 2001.
22. Charles CJ, Rademaker MT, Richards AM, Nicholls MG. Adrenomedullin augments the neurohumoral response to haemorrhage in non-pregnant but not pregnant sheep. Journal of Endocrinology 171(2):363-71, 2001.
23. Rademaker MT, Espiner EA. The Endocrine Heart. In: Principles and Practice of Endocrinology and Metabolism (3rd Edn). Kenneth Becker ed. Lippincott Williams & Wilkins, Philadelphia. Part V: The Adrenal Glands; Chpt 178, pp. 70-82, 2001.
24. Charles CJ, Nicholls MG, Rademaker MT, Richards AM. Comparative actions of adrenomedullin and nitroprusside: interactions with ANG II and norepinephrine. American Journal of Physiology - Regulatory Integrative & Comparative Physiology 281(6):R1887-94, 2001.
25. Rademaker MT, Charles CJ, Cooper GJS, Coy DH, Espiner EA, Lewis LK, Nicholls MG, Richards AM. Combined endopeptidase inhibition and adrenomedullin in sheep with experimental heart failure. Hypertension 39(1):93-8, 2002.
26. Rademaker MT and Espiner EA. Cardiovascular Hormones. In: Comprehensive Clinical Endocrinology (3rd edn). G. Michael Besser & Michael O. Thorner (eds). Elsevier Science Ltd, London. Chpt 33, pp.485-499, 2002.
27. Charles CJ. Nicholls MG. Rademaker MT. Richards AM. Adrenomedullin modulates the neurohumoral response to acute volume loading in normal conscious sheep. Journal of Endocrinology 173(1):123-9, 2002.
28. Rademaker MT, Charles CJ, Cooper GJS, Coy DH, Espiner EA, Lewis LK, Nicholls MG, Richards AM. Combined angiotensin-converting enzyme inhibition and adrenomedullin in an ovine model of heart failure. Clinical Science 102(6):653-60, 2002.
29. Rademaker MT, Charles CJ, Espiner EA, Nicholls MG, Richards AM. Chronic adrenomedullin administration in experimental heart failure. Hypertension (In press).
30. Rademaker MT, Charles CJ, Espiner EA, Fisher S, Frampton CM, Kirkpatrick CMJ, Lainchbury JG, Nicholls MG, Richards AM, Vale WW. Beneficial hemodynamic, endocrine and renal effects of urocortin in experimental heart failure: comparison with normal sheep. Journal of The Americam College of Cardiology (In press).
31. Rademaker MT, Cameron VA, Charles CJ, Lainchbury JG, Nicholls MG, Richards AM. Adrenomedullin and heart failure. Regulatory Peptides (In press).
32. Charles CJ, Lainchbury JG, Nicholls MG, Rademaker MT, Richards AM, Troughton RW. Adrenomedullin and the renin-angiotensin-aldosterone system. Regulatory Peptides (In press).

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